human NDUFA1 Over-expression AAV

Name 
AAV-h-NDUFA1
Cat No 
AAV-216470
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human NDUFA1.

AAV-216470
AAV-h-NDUFA1

Ready-to-use AAV expressing Human NDUFA1 (NADH:ubiquinone oxidoreductase subunit A1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CI-MWFE; MWFE; ZNF183
Description (Vector)
The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the 'hydrophobic protein' (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function.
Gene ID
4694
Gene Name (Vector)
NADH:ubiquinone oxidoreductase subunit A1
Gene Symbol
NDUFA1
HGNC ID
HGNC:7683
ORF Size (aa)
213
RefSeq ID
NM_004541
RefSeq Synonyms
NM_004541, BC000266,
Species
human
UniGene ID
Hs.534168

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.