mouse RPE65 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Rpe65.
shADV-270828
Ad-m-RPE65-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Rpe65 (retinal pigment epithelium 65). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
65kDa; A930029L06Rik; LCA2; Mord1; rd12; RP20
Description (Vector)
Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.
Gene ID
19892
Gene Name (Vector)
retinal pigment epithelium 65
Gene Symbol
Rpe65
ORF Size (aa)
1602
ORF Size (bp)
1602 bp
RefSeq ID
NM_029987
RefSeq Synonyms
NM_029987, BC130028,
Species
mouse
UniGene ID
Mm.131708
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.