mouse PPP2CA shRNA silencing Adenovirus

Name 
Ad-m-PPP2CA-shRNA
Cat No 
shADV-269223
Availability
Immediate
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Ppp2ca.

shADV-269223
Ad-m-PPP2CA-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ppp2ca (protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
PP2A; R75353
Description (Vector)
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at 'Ser-259'.
Gene ID
19052
Gene Name (Vector)
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
Gene Symbol
Ppp2ca
ORF Size (aa)
930
RefSeq ID
NM_019411
RefSeq Synonyms
NM_019411, BC054458, BC003856,
Species
mouse
UniGene ID
Mm.260288

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.