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mouse PAWR shRNA silencing Adenovirus

Name 
Ad-m-PAWR-shRNA
Cat No 
shADV-268104
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Pawr.

shADV-268104
Ad-m-PAWR-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Pawr (PRKC, apoptosis, WT1, regulator). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
2310001G03Rik; Par-4; PAR4
Description (Vector)
Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Gene ID
114774
Gene Name (Vector)
PRKC, apoptosis, WT1, regulator
Gene Symbol
Pawr
ORF Size (aa)
1002
ORF Size (bp)
1002 bp
RefSeq ID
NM_054056
RefSeq Synonyms
NM_054056, BC148861, BC148613,
Species
mouse
UniGene ID
Mm.391419

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.