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mouse MSH3 shRNA silencing Adenovirus

Name 
Ad-m-MSH3-shRNA
Cat No 
shADV-265045
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Msh3.

shADV-265045
Ad-m-MSH3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Msh3 (mutS homolog 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
D13Em1; Rep-3; Rep3
Description (Vector)
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
Gene ID
17686
Gene Name (Vector)
mutS homolog 3
Gene Symbol
Msh3
ORF Size (aa)
3288
ORF Size (bp)
3288 bp
RefSeq ID
NM_010829
RefSeq Synonyms
NM_010829, NM_001311120, BC150759,
Species
mouse
UniGene ID
Mm.343101

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.