human MRVI1 Over-expression AAV

Name 
AAV-h-MRVI1
Cat No 
AAV-215883
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human MRVI1.

AAV-215883
AAV-h-MRVI1

Ready-to-use AAV expressing Human MRVI1 (murine retrovirus integration site 1 homolog). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
IRAG; JAW1L
Description (Vector)
MRVI1 is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
Gene ID
10335
Gene Name (Vector)
murine retrovirus integration site 1 homolog
Gene Symbol
MRVI1
HGNC ID
HGNC:7237
ORF Size (aa)
1794
ORF Size (bp)
1794 bp
RefSeq ID
NM_001098579
RefSeq Synonyms
NM_130385, NM_001206881, NM_001206880, NM_001100167, NM_001100163, NM_001098579, BC117127,
Species
human
UniGene ID
Hs.501898

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.