mouse MERTK shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Mertk.
shADV-264502
Ad-m-MERTK-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Mertk (c-mer proto-oncogene tyrosine kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Eyk; Mer; nmf12; Nyk
Description (Vector)
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Gene ID
17289
Gene Name (Vector)
c-mer proto-oncogene tyrosine kinase
Gene Symbol
Mertk
ORF Size (aa)
2982
ORF Size (bp)
2982 bp
RefSeq ID
NM_008587
RefSeq Synonyms
NM_008587, BC157109, BC156360,
Species
mouse
UniGene ID
Mm.239655
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.