mouse MBP shRNA silencing Adenovirus

Name 
Ad-m-MBP-shRNA
Cat No 
shADV-264335
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Mbp.

shADV-264335
Ad-m-MBP-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Mbp (myelin basic protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C76307; golli-mbp; Hmbpr; jve; mld; R75289; shi
Description (Vector)
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
Gene ID
17196
Gene Name (Vector)
myelin basic protein
Gene Symbol
Mbp
ORF Size (aa)
588
RefSeq ID
NM_001025245
RefSeq Synonyms
NM_010777, NM_001025259, NM_001025258, NM_001025256, NM_001025255, NM_001025254, NM_001025251, NM_001025245, BC051094, BC004704,
Species
mouse
UniGene ID
Mm.454459

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.