mouse MAPK10 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Mapk10.
shADV-264210
Ad-m-MAPK10-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Mapk10 (mitogen-activated protein kinase 10). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C230008H04Rik; JNK3; JNK3B1; JNK3B2; p493F12; p54bSAPK; SAPK(beta); Serk2
Description (Vector)
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.
Gene ID
26414
Gene Name (Vector)
mitogen-activated protein kinase 10
Gene Symbol
Mapk10
ORF Size (aa)
1281
ORF Size (bp)
1281 bp
RefSeq ID
NM_009158
RefSeq Synonyms
NM_009158, NM_001318131, NM_001318102, NM_001310686, NM_001310685, NM_001310683, NM_001081567, BC046625,
Species
mouse
UniGene ID
Mm.472459
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.