mouse MAP3K5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Map3k5.
shADV-264189
Ad-m-MAP3K5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Map3k5 (mitogen-activated protein kinase kinase kinase 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
7420452D20Rik; ASK; ASK1; MAPKKK5; Mekk5
Description (Vector)
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
Gene ID
26408
Gene Name (Vector)
mitogen-activated protein kinase kinase kinase 5
Gene Symbol
Map3k5
ORF Size (aa)
4143
ORF Size (bp)
4143 bp
RefSeq ID
NM_008580
RefSeq Synonyms
NM_008580, BC133697, BC116628, BC116627,
Species
mouse
UniGene ID
Mm.6595
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.