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mouse MAD2L2 shRNA silencing Adenovirus

Name 
Ad-m-MAD2L2-shRNA
Cat No 
shADV-264071
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Mad2l2.

shADV-264071
Ad-m-MAD2L2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Mad2l2 (MAD2 mitotic arrest deficient-like 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
2310033C13Rik; G1-453-4; MAD2B; repro22; REV7
Description (Vector)
Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
Gene ID
71890
Gene Name (Vector)
MAD2 mitotic arrest deficient-like 2
Gene Symbol
Mad2l2
ORF Size (aa)
636
ORF Size (bp)
636 bp
RefSeq ID
NM_027985
RefSeq Synonyms
NM_027985, NM_001305420, BC071264, BC011282,
Species
mouse
UniGene ID
Mm.9648

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.