rat MAD2L2 shRNA silencing Adenovirus

Name
Ad-r-MAD2L2-shRNA

Cat No
shADV-292632

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Rat Mad2l2.

shADV-292632

Ad-r-MAD2L2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Rat Mad2l2 (MAD2 mitotic arrest deficient-like 2 (yeast)). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Description (Vector)

Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.

Gene ID

313702

Gene Name (Vector)

MAD2 mitotic arrest deficient-like 2 (yeast)

Gene Symbol

Mad2l2

ORF Size (aa)

705

ORF Size (bp)

705 bp

RefSeq ID

NM_001012106

RefSeq Synonyms

NM_001012106, BC087687,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.