mouse LATS2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Lats2.
shADV-263277
Ad-m-LATS2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Lats2 (large tumor suppressor 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4932411G09Rik; AV277261; AW228608
Description (Vector)
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor.
Gene ID
50523
Gene Name (Vector)
large tumor suppressor 2
Gene Symbol
Lats2
ORF Size (aa)
3129
ORF Size (bp)
3129 bp
RefSeq ID
NM_015771
RefSeq Synonyms
NM_153382, NM_015771, BC053028,
Species
mouse
UniGene ID
Mm.347899
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.