human MPP5 Over-expression AAV

Name 
AAV-h-MPP5
Cat No 
AAV-215722
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human MPP5.

AAV-215722
AAV-h-MPP5

Ready-to-use AAV expressing Human MPP5 (membrane palmitoylated protein 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
MAGUK p55 subfamily member 5; membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); PALS1; protein associated with lin seven 1; protein associated with Lin-7 1; stardust
Description (eCommerce)
Membrane palmitoylated protein 5 (MPP5) is a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. MPP5 participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289) [taken from NCBI Entrez Gene (Gene ID: 64398)].
Description (Vector)
MPP5 encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
64398
Gene Name (eCommerce)
membrane palmitoylated protein 5
Gene Name (Vector)
membrane palmitoylated protein 5
Gene Symbol
MPP5
HGNC ID
HGNC:18669
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2028
ORF Size (bp)
2028 bp
Protein Name (eCommerce)
MAGUK p55 subfamily member 5
RefSeq ID
NM_022474
RefSeq Synonyms
NM_022474, NM_001256550, BC129933, BC095485,
Research Areas
Hippo Signaling,Neurobiology,Signal Transduction
Research Areas (Faceted)
neurobiology,signal_transduction
Species
human
Target Sentence
Membrane palmitoylated protein 5 (MPP5) is a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. MPP5 participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289) [taken from NCBI Entrez Gene (Gene ID: 64398)].
UniGene ID
Hs.652312
UniProt ID (eCommerce)
Q8N3R9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.