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mouse KCNK18 shRNA silencing Adenovirus

Name 
Ad-m-KCNK18-shRNA
Cat No 
shADV-262681
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Kcnk18.

shADV-262681
Ad-m-KCNK18-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Kcnk18 (potassium channel, subfamily K, member 18). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Gm781; Tresk; Tresk-2; Trik
Description (Vector)
Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity).
Gene ID
332396
Gene Name (Vector)
potassium channel, subfamily K, member 18
Gene Symbol
Kcnk18
ORF Size (aa)
1185
ORF Size (bp)
1185 bp
RefSeq ID
NM_207261
RefSeq Synonyms
NM_207261, BC127137, BC127136,
Species
mouse
UniGene ID
Mm.329947

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.