mouse INTS3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Ints3.
shADV-262296
Ad-m-INTS3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ints3 (integrator complex subunit 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C77668
Description (Vector)
Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes|Function: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.
Gene ID
229543
Gene Name (Vector)
integrator complex subunit 3
Gene Symbol
Ints3
ORF Size (aa)
3126
ORF Size (bp)
3126 bp
RefSeq ID
NM_145540
RefSeq Synonyms
NM_178876, NM_145540, BC055344,
Species
mouse
UniGene ID
Mm.268564
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.