human MNT Over-expression AAV

Name 
AAV-h-MNT
Cat No 
AAV-215618
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human MNT.

AAV-215618
AAV-h-MNT

Ready-to-use AAV expressing Human MNT (MAX network transcriptional repressor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
bHLHd3; class D basic helix-loop-helix protein 3; MAD6; MAX binding protein; max-binding protein MNT; Max-interacting protein; MNT, MAX dimerization protein; MXD6; myc antagonist MNT; Protein ROX; ROX
Description (eCommerce)
Max-binding protein MNT binds DNA as a heterodimer with MAX and represses transcription. MNT binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3' [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q99583].
Description (Vector)
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.
Gene ID
4335
Gene Name (eCommerce)
MAX network transcriptional repressor
Gene Name (Vector)
MAX network transcriptional repressor
Gene Symbol
MNT
HGNC ID
HGNC:7188
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1749
ORF Size (bp)
1749 bp
Protein Name (eCommerce)
Max-binding protein MNT
RefSeq ID
NM_020310
RefSeq Synonyms
NM_020310, BC117563,
Research Areas
Aging,Apoptosis,Cell Cycle,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Max-binding protein MNT binds DNA as a heterodimer with MAX and represses transcription. MNT binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3' [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q99583].
UniGene ID
Hs.632239
UniProt ID (eCommerce)
Q99583

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.