human MLPH Over-expression AAV

Name 
AAV-h-MLPH
Cat No 
AAV-215540
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human MLPH.

AAV-215540
AAV-h-MLPH

Ready-to-use AAV expressing Human MLPH (melanophilin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
SLAC2-A
Description (Vector)
MLPH encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Gene ID
79083
Gene Name (Vector)
melanophilin
Gene Symbol
MLPH
HGNC ID
HGNC:29643
ORF Size (aa)
1719
ORF Size (bp)
1719 bp
RefSeq ID
NM_024101
RefSeq Synonyms
NM_024101, NM_001281474, NM_001281473, NM_001042467, BC051269, BC001653,
Species
human
UniGene ID
Hs.102406

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.