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mouse GLIS2 shRNA silencing Adenovirus

Name 
Ad-m-GLIS2-shRNA
Cat No 
shADV-260182
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Glis2.

shADV-260182
Ad-m-GLIS2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Glis2 (GLIS family zinc finger 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Gli5; Klf16; Nkl
Description (Vector)
Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity).
Gene ID
83396
Gene Name (Vector)
GLIS family zinc finger 2
Gene Symbol
Glis2
ORF Size (aa)
1566
ORF Size (bp)
1566 bp
RefSeq ID
NM_031184
RefSeq Synonyms
NM_031184, BC021517,
Species
mouse
UniGene ID
Mm.134072

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.