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human GLIS2 shRNA silencing Adenovirus

Name 
Ad-h-GLIS2-shRNA
Cat No 
shADV-209977
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human GLIS2.

shADV-209977
Ad-h-GLIS2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GLIS2 (GLIS family zinc finger 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
76
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
NKL; NPHP7
Description (Vector)
GLIS2 is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.
Gene ID
84662
Gene Name (Vector)
GLIS family zinc finger 2
Gene Symbol
GLIS2
HGNC ID
HGNC:29450
ORF Size (aa)
1575
ORF Size (bp)
1575 bp
RefSeq ID
NM_032575
RefSeq Synonyms
NM_032575, NM_001318918, BC146548, BC141548,
Species
human
UniGene ID
Hs.592087

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.