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mouse GABBR2 shRNA silencing Adenovirus

Name 
Ad-m-GABBR2-shRNA
Cat No 
shADV-259791
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Gabbr2.

shADV-259791
Ad-m-GABBR2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Gabbr2 (gamma-aminobutyric acid (GABA) B receptor, 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
GABABR2; Gb2; Gm425; Gpr51
Description (Vector)
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
Gene ID
242425
Gene Name (Vector)
gamma-aminobutyric acid (GABA) B receptor, 2
Gene Symbol
Gabbr2
ORF Size (aa)
2820
ORF Size (bp)
2820 bp
RefSeq ID
NM_001081141
RefSeq Synonyms
NM_001081141, BC156988, BC156087,
Species
mouse
UniGene ID
Mm.101909

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.