mouse CILP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Cilp.
shADV-255508
Ad-m-CILP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Cilp (cartilage intermediate layer protein, nucleotide pyrophosphohydrolase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
9830114D16; C130036G17Rik
Description (Vector)
Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
Gene ID
214425
Gene Name (Vector)
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Gene Symbol
Cilp
ORF Size (aa)
3555
ORF Size (bp)
3555 bp
RefSeq ID
NM_173385
RefSeq Synonyms
NM_173385, BC080666,
Species
mouse
UniGene ID
Mm.138455
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.