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mouse CHTF8 shRNA silencing Adenovirus

Name 
Ad-m-CHTF8-shRNA
Cat No 
shADV-255489
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Chtf8.

shADV-255489
Ad-m-CHTF8-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Chtf8 (CTF8, chromosome transmission fidelity factor 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
5830457O10Rik; Ctf8; Derpc
Description (Vector)
Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed|Function: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression.
Gene ID
214987
Gene Name (Vector)
CTF8, chromosome transmission fidelity factor 8
Gene Symbol
Chtf8
ORF Size (aa)
1602
ORF Size (bp)
1602 bp
RefSeq ID
NM_145412
RefSeq Synonyms
NM_145412, BC023107,
Species
mouse
UniGene ID
Mm.476806

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.