mouse CD8A shRNA silencing Adenovirus

Name 
Ad-m-CD8A-shRNA
Cat No 
shADV-255057
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Cd8a.

shADV-255057
Ad-m-CD8A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Cd8a (CD8 antigen, alpha chain). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BB154331; CD antigen CD8a; Ly-2; Ly-35; Ly-B; Lyt-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2
Description (eCommerce)
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain [taken from NCBI Entrez Gene (Gene ID: 925)].
Description (Vector)
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
Gene ID
12525
Gene Name (eCommerce)
CD8 antigen, alpha chain
Gene Name (Vector)
CD8 antigen, alpha chain
Gene Symbol
Cd8a
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
624
Protein Name (eCommerce)
T-cell surface glycoprotein CD8 alpha chain
RefSeq ID
NM_009857
RefSeq Synonyms
NM_009857, NM_001081110, BC030679,
Research Areas
Antigen Processing and Presentation,Host-Virus Interactions,Immune Cells and Tumor Markers,Immunology,Immuno-Oncology,Interleukin Signaling,Signal Transduction,immunology,cell_biology,T-cell Receptor Signaling
Research Areas (Faceted)
cell_biology,immuno_oncology,immunology,infectious_disease,signal_transduction
Species
mouse
Target Sentence
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain [taken from NCBI Entrez Gene (Gene ID: 925)].
UniGene ID
Mm.1858
UniProt ID (eCommerce)
P01731

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.