mouse CCNT1 shRNA silencing Adenovirus

Name 
Ad-m-CCNT1-shRNA
Cat No 
shADV-254888
Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Mouse Ccnt1.

shADV-254888
Ad-m-CCNT1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ccnt1 (cyclin T1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
2810478G24Rik; AI115585; CycT1
Description (Vector)
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.
Gene ID
12455
Gene Name (Vector)
cyclin T1
Gene Symbol
Ccnt1
ORF Size (aa)
2175
ORF Size (bp)
2175 bp
RefSeq ID
NM_009833
RefSeq Synonyms
NM_009833, BC131685,
Species
mouse
UniGene ID
Mm.86538

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.