mouse CATSPER4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Catsper4.
shADV-254583
Ad-m-CATSPER4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Catsper4 (cation channel, sperm associated 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4933412L05
Description (Vector)
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
Gene ID
329954
Gene Name (Vector)
cation channel, sperm associated 4
Gene Symbol
Catsper4
ORF Size (aa)
1329
ORF Size (bp)
1329 bp
RefSeq ID
NM_177866
RefSeq Synonyms
NM_177866, NM_001130030, BC108975, BC108974,
Species
mouse
UniGene ID
Mm.79072
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.