mouse LATS1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Lats1.
shADV-254322
Ad-m-LATS1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Lats1 (large tumor suppressor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW208599
Description (Vector)
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
Gene ID
16798
Gene Name (Vector)
large tumor suppressor
Gene Symbol
Lats1
ORF Size (aa)
3390
ORF Size (bp)
3390 bp
RefSeq ID
NM_010690
RefSeq Synonyms
NM_010690, BC158123, BC158092,
Species
mouse
UniGene ID
Mm.34083
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.