mouse BARD1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Bard1.
shADV-253620
Ad-m-BARD1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Bard1 (BRCA1 associated RING domain 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ENSMUSG00000060893; ENSMUSG00000073653
Description (Vector)
Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
Gene ID
12021
Gene Name (Vector)
BRCA1 associated RING domain 1
Gene Symbol
Bard1
ORF Size (aa)
2298
ORF Size (bp)
2298 bp
RefSeq ID
NM_007525
RefSeq Synonyms
NM_007525, BC128371, BC128370,
Species
mouse
UniGene ID
Mm.472810
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.