mouse XRN1 shRNA silencing Adenovirus

Name
Ad-m-XRN1-shRNA

Cat No
shADV-251610

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Mouse Xrn1.

shADV-251610

Ad-m-XRN1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Xrn1 (5′-3′ exoribonuclease 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

Dhm2; exo; mXrn1

Description (Vector)

Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).

Gene ID

24127

Gene Name (Vector)

5'-3' exoribonuclease 1

Gene Symbol

Xrn1

ORF Size (aa)

5172

ORF Size (bp)

5172 bp

RefSeq ID

NM_011916

RefSeq Synonyms

NM_011916, NM_001311130, BC156976, BC156133,

Species

mouse

UniGene ID

Mm.291179

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.