human MDM2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MDM2.
shADV-230831
Ad-h-MDM2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MDM2 (MDM2 proto-oncogene). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ACTFS; hdm2; HDMX
Description (Vector)
MDM2 is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.
Gene ID
4193
Gene Name (Vector)
MDM2 proto-oncogene
Gene Symbol
MDM2
HGNC ID
HGNC:6973
ORF Size (aa)
1491
ORF Size (bp)
1491 bp
RefSeq ID
NM_002392
RefSeq Synonyms
NM_002392, NM_001278462, NM_001145340, NM_001145339, NM_001145337, BC153117, BC148522,
Species
human
UniGene ID
Hs.484551
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.