human MCL1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MCL1.
shADV-230351
Ad-h-MCL1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MCL1 (BCL2 family apoptosis regulator). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BCL2 family apoptosis regulator; BCL2L3; bcl2-L-3; bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; EAT; induced myeloid leukemia cell differentiation protein Mcl-1; Mcl-1; mcl1/EAT; MCL1-ES; MCL1L; MCL1S; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1 (BCL2-related); TM
Description (eCommerce)
Myeloid cell leukemia sequence 1 (MCL1) is involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. MCL1 mediates its effects by interactions with a number of other regulators of apoptosis. Two transcripts from the MCL1 gene have been identified. Isoform 1 enhances cell survival, while isoforms 2 promotes apoptosis.
Description (Vector)
MCL1 encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
Gene ID
4170
Gene Name (eCommerce)
MCL1, BCL2 family apoptosis regulator
Gene Name (Vector)
BCL2 family apoptosis regulator
Gene Symbol
MCL1
HGNC ID
HGNC:6943
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1053
ORF Size (bp)
1053 bp
Protein Name (eCommerce)
Induced myeloid leukemia cell differentiation protein Mcl-1
RefSeq ID
NM_021960
RefSeq Synonyms
NM_182763, NM_021960, NM_001197320, BC107735, BC071897, BC017197,
Research Areas
Apoptosis,Cancer,Immunology,Interleukin Signaling,MicroRNAs in Cancer,Mitochondrion,PI3K/Akt Signaling,RNA Processing,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,genetics,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
Myeloid cell leukemia sequence 1 (MCL1) is involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. MCL1 mediates its effects by interactions with a number of other regulators of apoptosis. Two transcripts from the MCL1 gene have been identified. Isoform 1 enhances cell survival, while isoforms 2 promotes apoptosis.
UniGene ID
Hs.719112
UniProt ID (eCommerce)
Q07820
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.