human AIDA shRNA silencing Adenovirus

Name 
Ad-h-AIDA-shRNA
Cat No 
shADV-229459
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human AIDA.

shADV-229459
Ad-h-AIDA-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human AIDA (axin interactor, dorsalization associated). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
axin interaction partner and dorsalization antagonist; axin interactor, dorsalization-associated protein; C1orf80
Description (eCommerce)
Axin interactor and dorsalization-associated protein (AIDA) acts as a ventralizing factor during embryogenesis. By similarity AIDA is proposed to inhibit axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q96BJ3].
Gene ID
64853
Gene Name (eCommerce)
axin interactor, dorsalization associated
Gene Name (Vector)
axin interactor, dorsalization associated
Gene Symbol
AIDA
HGNC ID
HGNC:25761
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
921
ORF Size (bp)
921 bp
Protein Name (eCommerce)
Axin interactor, dorsalization-associated protein
RefSeq ID
NM_022831
RefSeq Synonyms
NM_022831, BC067805, BC015535,
Research Areas
JNK Signaling,Signal Transduction
Research Areas (Faceted)
signal_transduction
Species
human
Target Sentence
Axin interactor and dorsalization-associated protein (AIDA) acts as a ventralizing factor during embryogenesis. By similarity AIDA is proposed to inhibit axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q96BJ3].
UniGene ID
Hs.156625
UniProt ID (eCommerce)
Q96BJ3

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.