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human YY1 shRNA silencing Adenovirus

Name 
Ad-h-YY1-shRNA
Cat No 
shADV-228018
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human YY1.

shADV-228018
Ad-h-YY1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human YY1 (YY1 transcription factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DELTA; delta transcription factor; GADEVS; INO80 complex subunit S; INO80S; NF-E1; transcriptional repressor protein YY1; UCRBP; Yin and yang 1; Yin and Yang 1 protein; YIN-YANG-1; YY-1
Description (eCommerce)
YY1 (ying and yang 1) is a multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. YY1 may play an important role in development and differentiation. The function of YY1 as an activator or a repressor is specified by the presence of other proteins. For example it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence.
Description (Vector)
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.
Gene ID
7528
Gene Name (eCommerce)
YY1 transcription factor
Gene Name (Vector)
YY1 transcription factor
Gene Symbol
YY1
HGNC ID
HGNC:12856
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1245
Protein Name (eCommerce)
Transcriptional repressor protein YY1
RefSeq ID
NM_003403
RefSeq Synonyms
NM_003403, BC065366, BC037308,
Research Areas
DNA Damage/Repair,mTOR Signaling,Notch Signaling,p53 Signaling,RNA Binding,Signal Transduction,Spermatogenesis,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
YY1 (ying and yang 1) is a multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. YY1 may play an important role in development and differentiation. The function of YY1 as an activator or a repressor is specified by the presence of other proteins. For example it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence.
UniGene ID
Hs.388927
UniProt ID (eCommerce)
P25490

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.