mouse YY1 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-276494
Availability:
3-5 weeks
Name:
Ad-m-YY1-shRNA
This is an Adenovirus expressing shRNA for silencing of Mouse Yy1.
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Product Info
- Knockdown
- >90% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Yy1
- Gene Name
- YY1 transcription factor
- Gene ID
- 22632
- Gene Synonyms
- AW488674; NF-E1
- ORF Size
- 1245 bp
- RefSeq#
- NM_009537
- Gene Description
- Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions)|Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.
- UniGene ID
- Mm.458511
Related Products
Product | Cat No. |
---|---|
AAV-h-YY1 | AAV-228018 |
AAV-m-YY1 | AAV-276494 |
Ad-h-YY1 | ADV-228018 |
Ad-m-YY1 | ADV-276494 |
AAV-h-YY1-shRNA | shAAV-228018 |
AAV-m-YY1-shRNA | shAAV-276494 |
Ad-h-YY1-shRNA | shADV-228018 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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