human XPC shRNA silencing Adenovirus

Name 
Ad-h-XPC-shRNA
Cat No 
shADV-227906
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human XPC.

shADV-227906
Ad-h-XPC-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human XPC (XPC complex subunit, DNA damage recognition and repair factor). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DNA repair protein complementing XP-C cells; mutant xeroderma pigmentosum group C; p125; RAD4; Xeroderma pigmentosum group C-complementing protein; xeroderma pigmentosum, complementation group C; XP3; XPCC
Description (eCommerce)
Defects in XPC are a cause of xeroderma pigmentosum complementation group C, a rare autosomal recessive diseased characterized by hypersensitivity to sunlight and an elevated risk of skin cancer on sun-exposed areas. XPC is involved in nucleotide excision repair and performs its function as part of a heterodimeric complex with HHR23B. XPC has been found to play a role in the early stages of repair that involve incising damaged DNA.
Description (Vector)
XPC encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
Gene ID
7508
Gene Name (eCommerce)
XPC complex subunit, DNA damage recognition and repair factor
Gene Name (Vector)
XPC complex subunit, DNA damage recognition and repair factor
Gene Symbol
XPC
HGNC ID
HGNC:12816
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2823
ORF Size (bp)
2823 bp
Protein Name (eCommerce)
DNA repair protein complementing XP-C cells
RefSeq ID
NM_004628
RefSeq Synonyms
NM_004628, NM_001145769, BC016620,
Research Areas
Cell Cycle,DNA Damage/Repair
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Defects in XPC are a cause of xeroderma pigmentosum complementation group C, a rare autosomal recessive diseased characterized by hypersensitivity to sunlight and an elevated risk of skin cancer on sun-exposed areas. XPC is involved in nucleotide excision repair and performs its function as part of a heterodimeric complex with HHR23B. XPC has been found to play a role in the early stages of repair that involve incising damaged DNA.
UniGene ID
Hs.475538
UniProt ID (eCommerce)
Q01831

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.