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human VTA1 shRNA silencing Adenovirus

Name 
Ad-h-VTA1-shRNA
Cat No 
shADV-227571
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human VTA1.

shADV-227571
Ad-h-VTA1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human VTA1 (vesicle trafficking 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C6orf55; dopamine-responsive gene 1 protein; DRG1; DRG-1; homolog of mouse SKD1-binding protein 1; HSPC228; LIP5; LYST-interacting protein 5; My012; SBP1; SKD1-binding protein 1; vacuolar protein sorting-associated protein VTA1 homolog; vesicle (multivesicular body) trafficking 1; Vps20-associated 1 homolog
Description (eCommerce)
VTA1 is involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VTA1 is thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. It is involved in the sorting and down-regulation of EGFR (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NP79].
Description (Vector)
C6ORF55 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes (Ward et al., 2005 (PubMed 15644320)).(supplied by OMIM, Mar 2008)
Gene ID
51534
Gene Name (eCommerce)
vesicle trafficking 1
Gene Name (Vector)
vesicle trafficking 1
Gene Symbol
VTA1
HGNC ID
HGNC:20954
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
924
ORF Size (bp)
924 bp
Protein Name (eCommerce)
Vacuolar protein sorting-associated protein VTA1 homolog
RefSeq ID
NM_016485
RefSeq Synonyms
NM_016485, NM_001286372, NM_001286371, BC022536, BC006989, BC005937,
Research Areas
Host-Virus Interactions
Research Areas (Faceted)
infectious_disease
Species
human
Target Sentence
VTA1 is involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VTA1 is thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. It is involved in the sorting and down-regulation of EGFR (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NP79].
UniGene ID
Hs.431367
UniProt ID (eCommerce)
Q9NP79

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.