human VCP shRNA silencing Adenovirus

Name 
Ad-h-VCP-shRNA
Cat No 
shADV-227427
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human VCP.

shADV-227427
Ad-h-VCP-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human VCP (valosin containing protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
86
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
15S Mg(2+)-ATPase p97 subunit; CDC48; p97; TER ATPase; TERA; transitional endoplasmic reticulum ATPase; Valosin-containing protein; VCP
Description (eCommerce)
Valosin-containing protein (VCP) is a multifunctional protein that is proposed to be involved in vesicle transport and fusion for protein trafficking, 26S proteasome function in ubiquitin-based degradation pathways, and the assembly of peroxisomes. Mutations in the human VCP gene have been associated with diseases such as inclusion body myopathy, Paget disease of the bone, and frontotemporal dementia (IBMPFD). VCP can inhibit apoptosis and may play a role in tumorigenesis.
Description (Vector)
VCP is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.
Gene ID
7415
Gene Name (eCommerce)
valosin containing protein
Gene Name (Vector)
valosin containing protein
Gene Symbol
VCP
HGNC ID
HGNC:12666
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1428
ORF Size (bp)
1428 bp
Protein Name (eCommerce)
Transitional endoplasmic reticulum ATPase
RefSeq ID
NM_007126
RefSeq Synonyms
NM_007126, BC122550, BC121794, BC110913, BC007562,
Research Areas
Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Cancer,Complexome,DNA Damage/Repair,Fanconi anemia,Golgi Apparatus,Neurobiology,Neurodegeneration,Proteasome,Signal Transduction,Transport,Ubiquitination
Research Areas (Faceted)
cancer,signal_transduction,neurobiology,cell_biology,genetics,transcription_translation,cell_biology,neurobiology,genetics
Species
human
Target Sentence
Valosin-containing protein (VCP) is a multifunctional protein that is proposed to be involved in vesicle transport and fusion for protein trafficking, 26S proteasome function in ubiquitin-based degradation pathways, and the assembly of peroxisomes. Mutations in the human VCP gene have been associated with diseases such as inclusion body myopathy, Paget disease of the bone, and frontotemporal dementia (IBMPFD). VCP can inhibit apoptosis and may play a role in tumorigenesis.
UniGene ID
Hs.529782
UniProt ID (eCommerce)
P55072

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.