human USP18 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human USP18.
shADV-227289
Ad-h-USP18-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human USP18 (ubiquitin specific peptidase 18). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ISG43; UBP43
Description (Vector)
USP18 belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.
Gene ID
11274
Gene Name (Vector)
ubiquitin specific peptidase 18
Gene Symbol
USP18
HGNC ID
HGNC:12616
ORF Size (aa)
1119
RefSeq ID
NM_017414
RefSeq Synonyms
NM_017414, BC014896,
Species
human
UniGene ID
Hs.38260
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.