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human UQCRB shRNA silencing Adenovirus

Name 
Ad-h-UQCRB-shRNA
Cat No 
shADV-227245
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human UQCRB.

shADV-227245
Ad-h-UQCRB-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human UQCRB (ubiquinol-cytochrome c reductase binding protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6; UQPC
Description (Vector)
UQCRB encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X.
Gene ID
7381
Gene Name (Vector)
ubiquinol-cytochrome c reductase binding protein
Gene Symbol
UQCRB
HGNC ID
HGNC:12582
ORF Size (aa)
336
RefSeq ID
NM_006294
RefSeq Synonyms
NM_006294, NM_001254752, NM_001199975, BC005230,
Species
human
UniGene ID
Hs.131255

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.