mouse UPF3B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Upf3b.
shAAV-275663
AAV-m-UPF3B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Upf3b (UPF3 regulator of nonsense transcripts homolog B (yeast)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
5730594O13Rik; AI317193; AW541158; RENT3B; UPF3X
Description (Vector)
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is indepenedent of association with UPF2 and components of the EJC core.
Gene ID
68134
Gene Name (Vector)
UPF3 regulator of nonsense transcripts homolog B (yeast)
Gene Symbol
Upf3b
ORF Size (aa)
747
ORF Size (bp)
747 bp
RefSeq ID
NM_026573
RefSeq Synonyms
NM_026573, BC117770, BC117769,
Species
mouse
UniGene ID
Mm.271160
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.