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human UNC84B shRNA silencing Adenovirus

Name 
Ad-h-UNC84B-shRNA
Cat No 
shADV-227205
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SUN2.

shADV-227205
Ad-h-UNC84B-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SUN2 (Sad1 and UNC84 domain containing 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
UNC84B
Description (Vector)
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 (PubMed 19933576)).(supplied by OMIM, Nov 2010)
Gene ID
25777
Gene Name (Vector)
Sad1 and UNC84 domain containing 2
Gene Symbol
SUN2
HGNC ID
HGNC:14210
ORF Size (aa)
2217
ORF Size (bp)
2217 bp
RefSeq ID
NM_015374
RefSeq Synonyms
NM_015374, NM_001199580, NM_001199579, BC111717, BC111549, BC094797,
Species
human
UniGene ID
Hs.517622

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.