human UNC84B shRNA silencing AAV

Name
AAV-h-UNC84B-shRNA

Cat No
shAAV-227205

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SUN2.

shAAV-227205

AAV-h-UNC84B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SUN2 (Sad1 and UNC84 domain containing 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

UNC84B

Description (Vector)

SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 (PubMed 19933576)).(supplied by OMIM, Nov 2010)

Gene ID

25777

Gene Name (Vector)

Sad1 and UNC84 domain containing 2

Gene Symbol

SUN2

HGNC ID

HGNC:14210

ORF Size (aa)

2217

ORF Size (bp)

2217 bp

RefSeq ID

NM_015374

RefSeq Synonyms

NM_015374, NM_001199580, NM_001199579, BC111717, BC111549, BC094797,

Species

human

UniGene ID

Hs.517622

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.