human UNC119 shRNA silencing Adenovirus

Name
Ad-h-UNC119-shRNA

Cat No
shADV-227180

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human UNC119.

shADV-227180

Ad-h-UNC119-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human UNC119 (unc-119 lipid binding chaperone). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

HRG4; IMD13; POC7; POC7A

Description (Vector)

UNC119 is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.

Gene ID

9094

Gene Name (Vector)

unc-119 lipid binding chaperone

Gene Symbol

UNC119

HGNC ID

HGNC:12565

ORF Size (aa)

723

RefSeq ID

NM_005148

RefSeq Synonyms

NM_054035, NM_005148, NM_001330166, BC027176,

Species

human

UniGene ID

Hs.410455

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.