human UCP3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human UCP3.
shADV-227124
Ad-h-UCP3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human UCP3 (uncoupling protein 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SLC25A9
Description (Vector)
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.
Gene ID
7352
Gene Name (Vector)
uncoupling protein 3
Gene Symbol
UCP3
HGNC ID
HGNC:12519
ORF Size (aa)
630
RefSeq ID
NM_003356
RefSeq Synonyms
NM_022803, NM_003356, BC008392,
Species
human
UniGene ID
Hs.621879
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.