human TXNIP shRNA silencing Adenovirus

Name 
Ad-h-TXNIP-shRNA
Cat No 
shADV-226923
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TXNIP.

shADV-226923
Ad-h-TXNIP-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TXNIP (thioredoxin interacting protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ARRDC6; EST01027; HHCPA78; THIF; thioredoxin binding protein 2; Thioredoxin-binding protein 2; thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; VDUP1; vitamin D3 up-regulated protein 1
Description (eCommerce)
Thioredoxin-interacting protein (TXNIP) may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. TXNIP interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Also, TXNIP functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9H3M7].
Gene ID
10628
Gene Name (eCommerce)
thioredoxin interacting protein
Gene Name (Vector)
thioredoxin interacting protein
Gene Symbol
TXNIP
HGNC ID
HGNC:16952
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1176
ORF Size (bp)
1176 bp
Protein Name (eCommerce)
Thioredoxin-interacting protein
RefSeq ID
NM_006472
RefSeq Synonyms
NM_006472, NM_001313972, BC093704, BC093702,
Research Areas
Apoptosis,Cancer,Cell Cycle,Immunology,Innate Immunity,Signal Transduction,TNF Signaling,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,immunology,signal_transduction
Species
human
Target Sentence
Thioredoxin-interacting protein (TXNIP) may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. TXNIP interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Also, TXNIP functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9H3M7].
UniGene ID
Hs.715525
UniProt ID (eCommerce)
Q9H3M7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.