human TUBA1A shRNA silencing Adenovirus

Name 
Ad-h-TUBA1A-shRNA
Cat No 
shADV-226769
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TUBA1A.

shADV-226769
Ad-h-TUBA1A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TUBA1A (tubulin alpha 1a). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Alpha-tubulin 3; B-ALPHA-1; hum-a-tub1; hum-a-tub2; LIS3; TUBA3; tubulin alpha-1A chain; tubulin alpha-3 chain; tubulin B-alpha-1; tubulin, alpha, brain-specific
Description (eCommerce)
alpha-Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q71U36].
Description (Vector)
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene ID
7846
Gene Name (eCommerce)
tubulin alpha 1a
Gene Name (Vector)
tubulin alpha 1a
Gene Symbol
TUBA1A
HGNC ID
HGNC:20766
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1356
ORF Size (bp)
1356 bp
Protein Name (eCommerce)
Tubulin alpha-1A chain
RefSeq ID
NM_006009
RefSeq Synonyms
NM_006009, NM_001270400, NM_001270399, BC050637, BC006468,
Research Areas
Breast Cancer,Cancer,Cell Cycle,Cell Division,Cytoskeleton,Immunology,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,Parkinson's Disease,Parkin-Ubiquitin Proteasomal System,Protein Folding,T-cell Receptor Signaling,Translational Control
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,immunology,metabolism,neurobiology,cell_biology,signal_transduction,immunology,genetics,transcription_translation
Species
human
Target Sentence
alpha-Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q71U36].
UniGene ID
Hs.654422
UniProt ID (eCommerce)
Q71U36

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.