human TTRAP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TDP2.
shADV-226759
Ad-h-TTRAP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TDP2 (tyrosyl-DNA phosphodiesterase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; AD022; dJ30M3.3; EAP2; EAPII; epididymis secretory sperm binding protein; ETS1-associated protein 2; ETS1-associated protein II; hTDP2; TRAF and TNF receptor-associated protein; TTRAP; tyr-DNA phosphodiesterase 2; tyrosyl-DNA phosphodiesterase 2; tyrosyl-RNA phosphodiesterase; VPg unlinkase
Description (eCommerce)
TDP2 (5’-Tyr-DNA phosphodiesterase 2) is also known as TTRAP (TRAF and TNF receptor-associated protein). TTRAP is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. TTRAP also hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. TTRAP may also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O95551].
Description (Vector)
TDP2 encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.
Gene ID
51567
Gene Name (eCommerce)
tyrosyl-DNA phosphodiesterase 2
Gene Name (Vector)
tyrosyl-DNA phosphodiesterase 2
Gene Symbol
TDP2
HGNC ID
HGNC:17768
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1089
Protein Name (eCommerce)
Tyrosyl-DNA phosphodiesterase 2
RefSeq ID
NM_016614
RefSeq Synonyms
NM_016614, BC110375, BC017553,
Research Areas
CD40 Signaling,DNA Damage/Repair,Immunology,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
TDP2 (5’-Tyr-DNA phosphodiesterase 2) is also known as TTRAP (TRAF and TNF receptor-associated protein). TTRAP is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. TTRAP also hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. TTRAP may also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O95551].
UniGene ID
Hs.716397
UniProt ID (eCommerce)
O95551
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.