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human TNFRSF9 shRNA silencing Adenovirus

Name 
Ad-h-TNFRSF9-shRNA
Cat No 
shADV-226095
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TNFRSF9.

shADV-226095
Ad-h-TNFRSF9-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TNFRSF9 (TNF receptor superfamily member 9). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
4-1BB; 4-1BB ligand receptor; CD antigen CD137; CD137; CD137 antigen; CDw137; homolog of mouse 4-1BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; tumor necrosis factor receptor superfamily member 9
Description (eCommerce)
CD137 is a member of the TNF-receptor superfamily; it is a receptor that contributes to the clonal expansion, survival, and development of T cells. CD137 can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. [provided by RefSeq, Jul 2008] [taken from NCBI Entrez Gene (Gene ID: 3604)].
Description (Vector)
TNFRSF9 is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
Gene ID
3604
Gene Name (eCommerce)
TNF receptor superfamily member 9
Gene Name (Vector)
TNF receptor superfamily member 9
Gene Symbol
TNFRSF9
HGNC ID
HGNC:11924
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
768
Protein Name (eCommerce)
Tumor necrosis factor receptor superfamily member 9
RefSeq ID
NM_001561
RefSeq Synonyms
NM_001561, BC006196,
Research Areas
Apoptosis,Immunology,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
CD137 is a member of the TNF-receptor superfamily; it is a receptor that contributes to the clonal expansion, survival, and development of T cells. CD137 can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. [provided by RefSeq, Jul 2008] [taken from NCBI Entrez Gene (Gene ID: 3604)].
UniGene ID
Hs.654459
UniProt ID (eCommerce)
Q07011

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.