human TNFRSF11A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TNFRSF11A.
shADV-226071
Ad-h-TNFRSF11A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TNFRSF11A (TNF receptor superfamily member 11a). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD antigen CD265; CD265; FEO; LOH18CR1; loss of heterozygosity, 18, chromosomal region 1; ODFR; OFE; OPTB7; osteoclast differentiation factor receptor; OSTS; Paget disease of bone 2; PDB2; RANK; receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; TRANCER; tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Description (eCommerce)
RANK (receptor activator of NF-KB) is a member of the TNF-receptor superfamily. TNF-receptor family members can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. RANK and its ligand are important regulators of the interaction between T cells and dendritic cells. RANK is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells [taken from NCBI Entrez Gene (Gene ID: 8792)].
Description (Vector)
TNFRSF11A is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.
Gene ID
8792
Gene Name (eCommerce)
TNF receptor superfamily member 11a
Gene Name (Vector)
TNF receptor superfamily member 11a
Gene Symbol
TNFRSF11A
HGNC ID
HGNC:11908
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1848
ORF Size (bp)
1848 bp
Protein Name (eCommerce)
Tumor necrosis factor receptor superfamily member 11A
RefSeq ID
NM_003839
RefSeq Synonyms
NM_003839, NM_001278268, NM_001270951, NM_001270950, NM_001270949, BC152906,
Research Areas
Cancer,Immunology,Interleukin Signaling,JNK Signaling,NF-kB Signaling,Prolactin Signaling,RANKL-RANK Signaling,Signal Transduction
Research Areas (Faceted)
cancer,signal_transduction,immunology,signal_transduction
Species
human
Target Sentence
RANK (receptor activator of NF-KB) is a member of the TNF-receptor superfamily. TNF-receptor family members can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. RANK and its ligand are important regulators of the interaction between T cells and dendritic cells. RANK is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells [taken from NCBI Entrez Gene (Gene ID: 8792)].
UniGene ID
Hs.204044
UniProt ID (eCommerce)
Q9Y6Q6
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.