human TIMP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TIMP1.
shADV-225530
Ad-h-TIMP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TIMP1 (TIMP metallopeptidase inhibitor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CLGI; EPA; EPO; HCI; TIMP; TIMP-1
Description (Vector)
TIMP1 belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. TIMP1 is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
Gene ID
7076
Gene Name (Vector)
TIMP metallopeptidase inhibitor 1
Gene Symbol
TIMP1
HGNC ID
HGNC:11820
ORF Size (aa)
624
RefSeq ID
NM_003254
RefSeq Synonyms
NM_003254, BC000866,
Species
human
UniGene ID
Hs.522632
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.